Β-N-acetylhexosaminidase

{
  "id": "MLC-T-CHM-001401",
  "term": "Β-N-acetylhexosaminidase",
  "field": "Chemistry",
  "definition": "A lysosomal enzyme that catalyzes the hydrolysis of terminal N-acetyl-D-hexosamines from glycoconjugates. This enzyme exists as two major isoenzymes, Hex A and Hex B, which differ in their subunit composition. Deficiencies in this enzyme, particularly Hex A, lead to the accumulation of gangliosides, causing lysosomal storage disorders like Tay-Sachs disease.",
  "synonyms": [
    "hexosaminidase A"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Tay-Sachs disease"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 715 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/b-n-acetylhexosaminidase/"
}