Combinatorial joining

{
  "id": "MLC-T-CHM-002268",
  "term": "Combinatorial joining",
  "field": "Chemistry",
  "definition": "The molecular process that creates antigen receptor diversity by randomly selecting and linking one gene segment of each type (V, D, and J) to form a complete variable-region exon. This somatic recombination event occurs during the development of B and T lymphocytes. The joining of a V, D, and J segment forms the variable region of an immunoglobulin heavy chain, while a V and J segment join to form a light chain.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1146 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/combinatorial-joining/"
}