Conformational epitope

{
  "id": "MLC-T-CHM-002418",
  "term": "Conformational epitope",
  "field": "Chemistry",
  "definition": "An antigenic determinant on a protein that is formed by amino acid residues that are not contiguous in the primary sequence but are brought together in three-dimensional space by the protein's folding. Antibodies recognizing these epitopes bind to specific spatial arrangements of amino acids. These epitopes are often sensitive to denaturation of the protein.",
  "synonyms": [
    "discontinuous epitope"
  ],
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1148 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/conformational-epitope/"
}