Covalent drug

{
  "id": "MLC-T-CHM-002652",
  "term": "Covalent drug",
  "field": "Chemistry",
  "definition": "A pharmaceutical agent that forms a stable covalent bond with its molecular target, typically a protein. This irreversible or slowly reversible interaction can lead to sustained pharmacological effects. Many covalent drugs are designed to target specific amino acid residues in the active site of an enzyme.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "molecular target"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1731 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/covalent-drug/"
}