Critical organ concentration

{
  "id": "MLC-T-CHM-002696",
  "term": "Critical organ concentration",
  "field": "Chemistry",
  "definition": "The concentration of a toxic substance within a specific organ that is associated with the onset of a defined adverse effect. This internal dose metric is used in toxicology to relate the amount of a chemical in the target organ to its observed toxicity. It provides a more direct measure of the biologically effective dose than external exposure concentrations.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "critical concentration",
    "critical organ"
  ],
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1199 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/critical-organ-concentration/"
}