Critical effect

{
  "id": "MLC-T-CHM-002683",
  "term": "Critical effect",
  "field": "Chemistry",
  "definition": "The most sensitive adverse effect of a substance that occurs at the lowest dose or concentration, serving as the basis for risk assessment and regulatory decisions. This effect is considered the limiting factor for safe exposure, as preventing it would also prevent all other, less sensitive effects. Identifying the critical effect is a fundamental step in establishing acceptable daily intakes or exposure limits.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "critical concentration",
    "critical organ",
    "threshold"
  ],
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1199 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/critical-effect/"
}