Threshold

{
  "id": "MLC-T-CHM-012026",
  "term": "Threshold",
  "field": "Chemistry",
  "definition": "The dose or exposure concentration of a substance below which no detectable adverse effect is expected to occur in a defined population. At exposure levels below this point, an organism's adaptive and repair mechanisms are sufficient to prevent harm. For non-carcinogenic chemicals, regulatory bodies establish a reference dose or tolerable daily intake based on the threshold identified in toxicological studies.",
  "synonyms": [
    "threshold concentration",
    "threshold dose"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "critical effect",
    "estimated exposure concentration"
  ],
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1321 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/threshold/"
}