Threshold of toxicological concern

{
  "id": "MLC-T-CHM-012031",
  "term": "Threshold of toxicological concern",
  "field": "Chemistry",
  "definition": "A concept used in toxicology to establish a low level of exposure to a chemical below which there is a negligible probability of adverse health effects. This approach is applied to substances for which substance-specific toxicity data are limited or absent. It involves assigning a default exposure limit based on structural alerts and general toxicity data for similar compounds.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1322 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/threshold-of-toxicological-concern/"
}