Lowest observed adverse effect level

{
  "id": "MLC-T-CHM-006789",
  "term": "Lowest observed adverse effect level",
  "field": "Chemistry",
  "definition": "The lowest dose or concentration of a substance in a toxicity study that causes a statistically significant and biologically adverse effect in the exposed population compared to a control group. This level is used in risk assessment to establish a point of departure for setting exposure limits. It is often abbreviated as LOAEL.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "exposure",
    "morphology",
    "strain"
  ],
  "references": [
    "PAC, 1993, 65, 2003. 'Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993)' on page 2065 (https://doi.org/10.1351/pac199365092003)",
    "PAC, 2001, 73, 993. 'Risk assessment for occupational exposure to chemicals. A review of current methodology (IUPAC Technical Report)' on page 1023 (https://doi.org/10.1351/pac200173060993)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/lowest-observed-adverse-effect-level/"
}