Immunoglobulin E-mediated hypersensitivity

{
  "id": "MLC-T-CHM-005678",
  "term": "Immunoglobulin E-mediated hypersensitivity",
  "field": "Chemistry",
  "definition": "An allergic reaction, also known as a type I hypersensitivity reaction, that is triggered by the binding of an allergen to immunoglobulin E (IgE) antibodies. Upon initial exposure to an allergen, susceptible individuals produce specific IgE antibodies that bind to the surface of mast cells and basophils. Subsequent exposure to the same allergen causes cross-linking of these bound IgE molecules, leading to rapid degranulation of the cells and the release of inflammatory mediators like histamine, which produce the symptoms of an allergic reaction.",
  "synonyms": [
    "IgE-Mediated Hypersensitivity"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "allergen",
    "allergic",
    "immunoglobulin E"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1188 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/immunoglobulin-e-mediated-hypersensitivity/"
}