Isotope dilution mass spectrometry

{
  "id": "MLC-T-CHM-006232",
  "term": "Isotope dilution mass spectrometry",
  "field": "Chemistry",
  "definition": "A highly accurate quantitative analytical technique that combines the principle of isotope dilution with mass spectrometry for precise determination of analyte concentrations. A known amount of an isotopically enriched standard of the analyte is added to the sample, and the resulting change in the isotopic ratio is measured by mass spectrometry. This method is considered a primary reference method due to its high accuracy and independence from matrix effects.",
  "subject": "Analytical Chemistry",
  "see_also": [
    "surrogate internal standard"
  ],
  "references": [
    "PAC, 2013, 85, 1515. 'Definitions of terms relating to mass spectrometry (IUPAC Recommendations 2013)' on page 1556 (https://doi.org/10.1351/PAC-REC-06-04-06)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/isotope-dilution-mass-spectrometry/"
}