Lambert-Eaton myasthenic syndrome

{
  "id": "MLC-T-CHM-006427",
  "term": "Lambert-Eaton myasthenic syndrome",
  "field": "Chemistry",
  "definition": "A rare autoimmune condition characterized by impaired communication between nerves and muscles, leading to muscle weakness and fatigue. This disorder arises from autoantibodies targeting voltage-gated calcium channels on presynaptic nerve terminals, which reduces the release of acetylcholine. It is frequently associated with small cell lung cancer, making it a paraneoplastic syndrome.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "paraneoplastic autoimmune syndrome",
    "autoantibody"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1200 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/lambert-eaton-myasthenic-syndrome/"
}