Litchfield-Wilcoxon method

{
  "id": "MLC-T-CHM-006702",
  "term": "Litchfield-Wilcoxon method",
  "field": "Chemistry",
  "definition": "A graphical and statistical procedure for estimating the median effective dose (ED50) or median lethal dose (LD50) and their confidence intervals from quantal dose-response data. This method involves plotting the percentage of responders (e.g., mortality) against the logarithm of the dose on probit paper, allowing for the determination of the dose that elicits a response in 50% of the tested population. It is commonly applied in toxicology and pharmacology studies.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2009, 81, 829. 'Glossary of terms used in ecotoxicology (IUPAC Recommendations 2009)' on page 906 (https://doi.org/10.1351/PAC-REC-08-07-09)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/litchfield-wilcoxon-method/"
}