OKT3

{
  "id": "MLC-T-CHM-008208",
  "term": "OKT3",
  "field": "Chemistry",
  "definition": "A murine monoclonal antibody that targets the CD3 receptor complex on the surface of human T-lymphocytes, inducing their rapid removal from circulation. This T-cell depletion results in potent immunosuppression. OKT3 was the first monoclonal antibody approved for therapeutic use in humans, primarily for reversing acute rejection of solid organ transplants, such as kidneys.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "antibody therapy",
    "immunosuppressant",
    "rejection"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1223 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/okt3/"
}