Humanized antibody

{
  "id": "MLC-T-CHM-005426",
  "term": "Humanized antibody",
  "field": "Chemistry",
  "definition": "A type of monoclonal antibody engineered to reduce immunogenicity when administered to humans, typically derived from non-human species like mice. This modification involves replacing most of the non-human antibody sequence with human sequences, retaining only the antigen-binding regions (complementarity-determining regions) from the original antibody. These antibodies are widely used in therapeutic applications to treat diseases such as cancer and autoimmune disorders.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "complementarity-determining region",
    "therapeutic antibody"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1178 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/humanized-antibody/"
}