Pyrogen

{
  "id": "MLC-T-CHM-009702",
  "term": "Pyrogen",
  "field": "Chemistry",
  "definition": "Any substance that induces fever when introduced into the body. These substances can be exogenous, such as bacterial endotoxins, or endogenous, like certain cytokines released by immune cells. Pyrogens act by stimulating the release of prostaglandins in the hypothalamus, which then reset the body's thermoregulatory set point.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1237 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/pyrogen/"
}