Reverse immunology

{
  "id": "MLC-T-CHM-010313",
  "term": "Reverse immunology",
  "field": "Chemistry",
  "definition": "A strategy for finding T-cell epitopes that starts from a protein or gene sequence rather than from T cells with a known response. Peptides are scored with algorithms that predict binding to a chosen MHC molecule, and the best candidates are then synthesized and tested for recognition by T cells. It has been applied to tumor antigens and to vaccine design.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "antigenic",
    "peptide-binding groove"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1240 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/reverse-immunology/"
}