Peptide-binding groove

{
  "id": "MLC-T-CHM-008612",
  "term": "Peptide-binding groove",
  "field": "Chemistry",
  "definition": "A specific cleft or pocket located on the surface of major histocompatibility complex (MHC) molecules, responsible for binding and presenting peptide antigens to T cells. This groove's structure determines which peptides can be accommodated, influencing the immune response. MHC class I molecules bind shorter peptides, while MHC class II molecules bind longer ones.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "antigen-presenting groove",
    "major histocompatibility complex class II molecule",
    "major histocompatibility complex class I molecule"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1226 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/peptide-binding-groove/"
}