Antigen-presenting groove

{
  "id": "MLC-T-CHM-000687",
  "term": "Antigen-presenting groove",
  "field": "Chemistry",
  "definition": "A specific binding cleft located on the surface of major histocompatibility complex (MHC) molecules, which accommodates and displays peptide fragments of antigens. This groove is formed by the alpha helices and beta sheets of the MHC molecule. T-cell receptors recognize the combination of the peptide and the MHC molecule within this groove.",
  "synonyms": [
    "antigen-binding groove"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T-cell receptor",
    "antigen presentation",
    "major histocompatibility complex molecule"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1125 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/antigen-presenting-groove/"
}