Major histocompatibility complex restriction

{
  "id": "MLC-T-CHM-006933",
  "term": "Major histocompatibility complex restriction",
  "field": "Chemistry",
  "definition": "The requirement that a T lymphocyte can only recognize and respond to a foreign peptide antigen when it is presented by a specific major histocompatibility complex (MHC) molecule. Cytotoxic T cells recognize antigens presented by MHC class I molecules, while helper T cells recognize antigens on MHC class II molecules. This specificity is established during T cell development in the thymus.",
  "synonyms": [
    "MHC restriction",
    "restriction (in immunology)"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T lymphocyte",
    "haplotype",
    "major histocompatibility complex molecule",
    "prime"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1209 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/major-histocompatibility-complex-restriction/"
}