Invariant chain

{
  "id": "MLC-T-CHM-006045",
  "term": "Invariant chain",
  "field": "Chemistry",
  "definition": "A non-polymorphic protein that associates with newly synthesized major histocompatibility complex (MHC) class II molecules in the endoplasmic reticulum. It prevents peptides and proteins within the endoplasmic reticulum from binding to the class II molecule's peptide-binding groove. After transport to an endosome, the invariant chain is proteolytically cleaved, leaving only a small fragment called CLIP in the binding groove.",
  "synonyms": [
    "CD74"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "endosome",
    "major histocompatibility complex",
    "major histocompatibility complex class III molecule"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1196 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/invariant-chain/"
}