Saturable elimination

{
  "id": "MLC-T-CHM-010523",
  "term": "Saturable elimination",
  "field": "Chemistry",
  "definition": "A pharmacokinetic process where the rate of elimination of a substance from the body becomes constant once a certain concentration is reached, due to the limited capacity of the enzymes or transporters involved. At low concentrations, elimination is typically first-order, but as concentrations increase, the elimination pathways become saturated. This leads to a disproportionate increase in drug levels with increasing dose, as seen with ethanol metabolism.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1306 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/saturable-elimination/"
}