Sensitized strain

{
  "id": "MLC-T-CHM-010748",
  "term": "Sensitized strain",
  "field": "Chemistry",
  "definition": "A model organism strain that carries a mutation in a metabolic or signaling pathway which causes no visible change in phenotype on its own but leaves the animal more responsive to a second change elsewhere in the same pathway. Geneticists use such backgrounds in sensitized screens to find enhancers and suppressors, because weakly interacting mutations that would go unnoticed in a normal strain then produce a visible effect.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 803 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/sensitized-strain/"
}