Spike

{
  "id": "MLC-T-CHM-011193",
  "term": "Spike",
  "field": "Chemistry",
  "definition": "The addition of a known amount of an analyte to a sample matrix to assess analytical recovery or to calibrate a measurement. This process allows for the evaluation of matrix effects and the accuracy of the analytical method. The recovery percentage is calculated by comparing the measured concentration to the expected concentration after spiking.",
  "subject": "Analytical Chemistry",
  "see_also": [
    "recovered quantity value ratio"
  ],
  "references": [
    "PAC, 2021, 93, 997. 'Metrological and quality concepts in analytical chemistry (IUPAC Recommendations 2021)' on page 1017 (https://doi.org/10.1515/pac-2019-0819)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/spike/"
}