Surrogate light chain

{
  "id": "MLC-T-CHM-011689",
  "term": "Surrogate light chain",
  "field": "Chemistry",
  "definition": "A protein complex in developing B lymphocytes that substitutes for a conventional immunoglobulin light chain. It pairs with the immunoglobulin heavy chain to form the pre-B cell receptor on the surface of pre-B cells. This complex consists of two non-covalently linked proteins, VpreB and λ5, and its successful assembly signals the cell to proceed with maturation.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "light chain",
    "pre-B cell"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1248 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/surrogate-light-chain/"
}