¹⁵N-NOESY-HSQC

{
  "id": "MLC-T-CHM-000003",
  "term": "¹⁵N-NOESY-HSQC",
  "field": "Chemistry",
  "definition": "A three-dimensional nuclear magnetic resonance (NMR) experiment that combines Nuclear Overhauser Effect Spectroscopy (NOESY) with Heteronuclear Single Quantum Coherence (HSQC) to correlate spatially close protons with directly bonded protons and nitrogen-15 nuclei. This technique is particularly useful in structural biology for determining the three-dimensional structure of proteins and nucleic acids. It provides through-space proton-proton correlations and through-bond proton-nitrogen correlations, aiding in resonance assignment and fold determination.",
  "subject": "Analytical Chemistry",
  "see_also": [
    "three-dimensional nuclear magnetic resonance spectroscopy",
    "nuclear Overhauser effect",
    "nuclear magnetic resonance spectrum"
  ],
  "references": [
    "PAC, 2021, 93, 647. 'Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)' on page 680 (https://doi.org/10.1515/pac-2019-0203)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/15n-noesy-hsqc/"
}