¹⁵N-TOCSY-HSQC

{
  "id": "MLC-T-CHM-000004",
  "term": "¹⁵N-TOCSY-HSQC",
  "field": "Chemistry",
  "definition": "A three-dimensional nuclear magnetic resonance (NMR) experiment that combines Total Correlation Spectroscopy (TOCSY) with Heteronuclear Single Quantum Coherence (HSQC) to correlate protons within a spin system with directly bonded protons and nitrogen-15 nuclei. This technique is widely used in structural biology for assigning resonances in proteins and other nitrogen-containing biomolecules. It provides through-bond proton-proton correlations within an amino acid residue and through-bond proton-nitrogen correlations, facilitating sequential assignment.",
  "subject": "Analytical Chemistry",
  "see_also": [
    "three-dimensional nuclear magnetic resonance spectroscopy",
    "total correlation spectroscopy"
  ],
  "references": [
    "PAC, 2021, 93, 647. 'Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)' on page 680 (https://doi.org/10.1515/pac-2019-0203)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/15n-tocsy-hsqc/"
}