Allosteric antagonist

{
  "id": "MLC-T-CHM-000433",
  "term": "Allosteric antagonist",
  "field": "Chemistry",
  "definition": "A substance that binds to an allosteric site on a receptor, distinct from the orthosteric binding site, and reduces the efficacy or affinity of an agonist. This binding induces a conformational change in the receptor, thereby modulating its activity without directly competing with the agonist for its binding site. It can decrease the maximum response of the receptor.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "noncompetitive antagonist"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1726 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/allosteric-antagonist/"
}