Noncompetitive antagonist

{
  "id": "MLC-T-CHM-008010",
  "term": "Noncompetitive antagonist",
  "field": "Chemistry",
  "definition": "A type of receptor antagonist that binds to a site on the receptor distinct from the agonist binding site, or binds irreversibly to the agonist binding site. This binding prevents the agonist from producing a maximal effect, even at high concentrations, by altering the receptor's conformation or reducing the number of available receptors. The effect cannot be overcome by increasing agonist concentration.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "allosteric antagonist"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1743 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/noncompetitive-antagonist/"
}