Orthosteric site

{
  "id": "MLC-T-CHM-008343",
  "term": "Orthosteric site",
  "field": "Chemistry",
  "definition": "The primary binding site on a receptor where the endogenous ligand normally interacts to produce a physiological response. Drugs that bind to this site are called orthosteric ligands and can act as agonists or antagonists, directly competing with the natural ligand. This site is distinct from allosteric sites, which are located elsewhere on the receptor.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "allosteric site"
  ],
  "references": [
    "PAC, 2011, 83, 1129. 'Glossary of terms used in biomolecular screening (IUPAC Recommendations 2011)' on page 1150 (https://doi.org/10.1351/PAC-REC-09-05-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/orthosteric-site/"
}