Amyloid plaque

{
  "id": "MLC-T-CHM-000530",
  "term": "Amyloid plaque",
  "field": "Chemistry",
  "definition": "Extracellular deposits of aggregated beta-amyloid (β-amyloid) peptides that accumulate in the brain tissue of individuals with Alzheimer's disease. These insoluble protein aggregates are a hallmark pathological feature of the disease, contributing to neuronal dysfunction and cognitive decline. The plaques are formed from the proteolytic cleavage of amyloid precursor protein.",
  "synonyms": [
    "neuritic plaque",
    "senile plaque"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Alzheimer disease",
    "brain",
    "β-amyloid"
  ],
  "references": [
    "PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 846 (https://doi.org/10.1515/pac-2015-0103)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/amyloid-plaque/"
}