Autoimmune regulator

{
  "id": "MLC-T-CHM-000983",
  "term": "Autoimmune regulator",
  "field": "Chemistry",
  "definition": "A transcription factor that controls the expression of a wide array of tissue-specific antigens within the medullary thymic epithelial cells of the thymus. This expression facilitates the elimination of self-reactive T-cells, a process known as negative selection, which establishes central immunological tolerance. Mutations in the gene encoding this protein cause the rare genetic disorder Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "immunological tolerance"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1131 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/autoimmune-regulator/"
}