Foxp3

{
  "id": "MLC-T-CHM-004622",
  "term": "Foxp3",
  "field": "Chemistry",
  "definition": "A protein that functions as a transcription factor required for the development and suppressive function of regulatory T cells. These cells, which include the CD4+/CD25+ T cell population, maintain immunological self-tolerance and prevent autoimmune reactions. Mutations in the gene encoding Foxp3 cause a severe disorder known as immunodysregulation-polyendocrinopathy-enteropathy, X-linked (IPEX) syndrome.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "CD4+/CD25+ T cell",
    "autoimmune",
    "immunodysregulation-polyendocrinopathy-enteropathy, X-linked"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1165 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/foxp3/"
}