Negative selection

{
  "id": "MLC-T-CHM-007806",
  "term": "Negative selection",
  "field": "Chemistry",
  "definition": "The immunological process by which developing T lymphocytes and B lymphocytes that recognize and bind strongly to self-antigens are eliminated, primarily through apoptosis. This process occurs in the primary lymphoid organs, the thymus for T cells and the bone marrow for B cells. Negative selection is a primary mechanism for establishing central tolerance, preventing the maturation of self-reactive lymphocytes that could cause autoimmune disease.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "B lymphocyte",
    "T lymphocyte",
    "autoimmune",
    "bone marrow",
    "major histocompatibility complex molecule",
    "autoantigen"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1220 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/negative-selection/"
}