Peripheral tolerance

{
  "id": "MLC-T-CHM-008653",
  "term": "Peripheral tolerance",
  "field": "Chemistry",
  "definition": "An immunological process that induces unresponsiveness in self-reactive T cells and B cells after they have matured and migrated from the primary lymphoid organs to the periphery. This mechanism prevents autoimmune reactions by deleting, inactivating (anergy), or suppressing lymphocytes that recognize self-antigens present in peripheral tissues. Regulatory T cells (Tregs) are a major contributor to peripheral tolerance by actively suppressing the activation and function of self-reactive effector lymphocytes.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "lymphoid tissue",
    "immunological tolerance"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1227 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/peripheral-tolerance/"
}