Anergy

{
  "id": "MLC-T-CHM-000582",
  "term": "Anergy",
  "field": "Chemistry",
  "definition": "A state of functional unresponsiveness in lymphocytes, such as T or B cells, following exposure to a specific antigen. The cell remains alive but is unable to mount a productive immune response, such as proliferation or cytokine secretion, upon subsequent encounters with that antigen. This condition is a key mechanism for maintaining peripheral tolerance, preventing the immune system from attacking the body's own tissues by inactivating self-reactive lymphocytes that escape deletion in the thymus.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "B-1/B-2 cells",
    "T lymphocyte",
    "autoantigen",
    "clonal anergy",
    "recall antigen",
    "self-tolerance"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1123 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/anergy/"
}