Clonal anergy

{
  "id": "MLC-T-CHM-002126",
  "term": "Clonal anergy",
  "field": "Chemistry",
  "definition": "A state of unresponsiveness in T lymphocytes or B lymphocytes that have encountered an antigen but did not receive the necessary co-stimulatory signals for full activation. This condition prevents an immune response to self-antigens, contributing to immunological tolerance. Anergic cells are unable to proliferate or differentiate into effector cells upon subsequent antigen exposure.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T-cell receptor",
    "major histocompatibility complex molecule",
    "autoantigen",
    "self-tolerance",
    "thymic",
    "pre-T cell"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1144 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/clonal-anergy/"
}