Clonal indifference

{
  "id": "MLC-T-CHM-002129",
  "term": "Clonal indifference",
  "field": "Chemistry",
  "definition": "A state where lymphocytes, despite recognizing a self-antigen, do not mount an immune response because the antigen concentration or presentation is below the threshold required for activation. These cells are not deleted or anergized but remain functionally inert. This mechanism contributes to self-tolerance, particularly for antigens present at low levels.",
  "synonyms": [
    "clonal ignorance"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "B lymphocyte",
    "T lymphocyte",
    "self-tolerance"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1145 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/clonal-indifference/"
}