Immunological ignorance

{
  "id": "MLC-T-CHM-005685",
  "term": "Immunological ignorance",
  "field": "Chemistry",
  "definition": "A state where potentially autoreactive lymphocytes exist in the body but do not cause autoimmune disease because they are not activated. This occurs when the concentration of self-antigen is too low, or the antigen is sequestered in a location inaccessible to immune cells. Such lymphocytes remain functionally inert despite their specificity for self-components.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T lymphocyte",
    "T-cell receptor",
    "autoantigen",
    "autoimmune"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1189 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/immunological-ignorance/"
}