Self-tolerance

{
  "id": "MLC-T-CHM-010716",
  "term": "Self-tolerance",
  "field": "Chemistry",
  "definition": "The state of immunological unresponsiveness to an individual's own antigens, preventing the immune system from attacking healthy tissues. This tolerance is established during lymphocyte development through processes like clonal deletion and anergy, where self-reactive immune cells are eliminated or inactivated. Failure of self-tolerance can lead to autoimmune diseases.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "anergy",
    "autoantigen",
    "autoimmune disease",
    "autoimmunity",
    "clonal deletion",
    "clonal indifference",
    "idiotype network",
    "immune deviation",
    "vetoing"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1243 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/self-tolerance/"
}