Central tolerance

{
  "id": "MLC-T-CHM-001792",
  "term": "Central tolerance",
  "field": "Chemistry",
  "definition": "A process by which self-reactive lymphocytes are eliminated or inactivated during their development in primary lymphoid organs. This mechanism prevents the immune system from attacking the body's own tissues. It primarily occurs in the thymus for T lymphocytes and in the bone marrow for B lymphocytes.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "B lymphocyte",
    "T lymphocyte",
    "anergy",
    "bone marrow",
    "lymphocyte",
    "immunological tolerance"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1142 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/central-tolerance/"
}