Double-negative cell

{
  "id": "MLC-T-CHM-003414",
  "term": "Double-negative cell",
  "field": "Chemistry",
  "definition": "A type of T lymphocyte precursor cell found in the thymus that lacks both the CD4 and CD8 co-receptor proteins on its surface. These cells represent an early stage of T cell development before commitment to either the helper or cytotoxic T cell lineage. They undergo further differentiation and selection processes within the thymus.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "CD4",
    "CD8",
    "immature",
    "T lymphocyte",
    "coreceptor",
    "pre-T cell"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1159 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/double-negative-cell/"
}