Double-positive cell

{
  "id": "MLC-T-CHM-003415",
  "term": "Double-positive cell",
  "field": "Chemistry",
  "definition": "A type of T lymphocyte precursor cell found in the thymus that simultaneously expresses both the CD4 and CD8 co-receptor proteins on its surface. These cells are an intermediate stage in T cell development, undergoing positive and negative selection processes. They eventually differentiate into single-positive CD4+ or CD8+ T cells.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "CD4",
    "CD8",
    "immature",
    "T lymphocyte",
    "coreceptor",
    "pre-T cell"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1159 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/double-positive-cell/"
}