Bone morphogenetic protein-4

{
  "id": "MLC-T-CHM-001433",
  "term": "Bone morphogenetic protein-4",
  "field": "Chemistry",
  "definition": "A specific protein within the bone morphogenetic protein family that acts as a signaling molecule in embryonic development. It establishes ventral cell fates in the early embryo by acting as a ventralizing morphogen. Its activity is antagonized by dorsalizing factors, such as chordin and noggin, which are secreted by the Spemann-Mangold organizer, thereby creating a concentration gradient that patterns the dorsal-ventral axis.",
  "synonyms": [
    "bone morphogenic protein-4 (BMP4)"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "bone morphogenetic protein",
    "Spemann organizer",
    "dorsal",
    "notochord",
    "sonic hedgehog",
    "ventral"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 731 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/bone-morphogenetic-protein-4/"
}