Chaperone-mediated autophagy

{
  "id": "MLC-T-CHM-001876",
  "term": "Chaperone-mediated autophagy",
  "field": "Chemistry",
  "definition": "A highly selective pathway for the degradation of specific cytosolic proteins within lysosomes. In this process, a chaperone protein, such as Hsc70, recognizes a specific pentapeptide motif (KFERQ-like) on a substrate protein and delivers it to the lysosomal membrane. The substrate then unfolds and is translocated into the lysosome for degradation via the lysosome-associated membrane protein 2A (LAMP-2A) receptor.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "autophagy"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1142 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/chaperone-mediated-autophagy/"
}