Cytotoxic T lymphocyte antigen 4

{
  "id": "MLC-T-CHM-002843",
  "term": "Cytotoxic T lymphocyte antigen 4",
  "field": "Chemistry",
  "definition": "A protein receptor found on the surface of T cells that acts as an immune checkpoint, downregulating immune responses. It competes with CD28 for binding to B7 molecules on antigen-presenting cells, thereby inhibiting T cell activation. This molecule is a target for certain cancer immunotherapies.",
  "synonyms": [
    "CD152"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "B7 molecule",
    "T lymphocyte",
    "lymphocyte activation",
    "autoimmune disease"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1154 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/cytotoxic-t-lymphocyte-antigen-4/"
}