indolamine-2,3-dioxygenase

{
  "id": "MLC-T-CHM-005791",
  "term": "indolamine-2,3-dioxygenase",
  "field": "Chemistry",
  "definition": "A heme-containing enzyme that catalyzes the first and rate-limiting step in the catabolism of the amino acid tryptophan along the kynurenine pathway. This enzyme's activity is induced by inflammatory signals, particularly interferon-gamma, and leads to local tryptophan depletion. By depleting tryptophan, the enzyme suppresses T lymphocyte proliferation, a mechanism involved in immune tolerance.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T lymphocyte",
    "tryptophan"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1193 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/indolamine-23-dioxygenase/"
}