Induced pluripotent stem cell

{
  "id": "MLC-T-CHM-013189",
  "term": "Induced pluripotent stem cell",
  "field": "Chemistry",
  "definition": "A pluripotent stem cell produced from a differentiated adult somatic cell, such as a skin fibroblast or a blood cell, by forcing expression of reprogramming factors, classically Oct4, Sox2, Klf4, and c-Myc. Like embryonic stem cells, which derive from the inner cell mass of the blastocyst, these cells self-renew and can differentiate into derivatives of all three germ layers. Takahashi and Yamanaka first made them from mouse fibroblasts in 2006.",
  "synonyms": [
    "iPS cell"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "pluripotent",
    "adult"
  ],
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 768 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/induced-pluripotent-stem-cell/"
}