Inflammasome

{
  "id": "MLC-T-CHM-005828",
  "term": "Inflammasome",
  "field": "Chemistry",
  "definition": "A large, intracellular multiprotein complex that detects pathogenic microorganisms and sterile stressors, initiating an inflammatory response. Upon activation, the inflammasome oligomerizes and recruits pro-caspase-1, leading to its cleavage and activation. Activated caspase-1 then processes pro-inflammatory cytokines like pro-interleukin-1β (pro-IL-1β) and pro-IL-18 into their mature, active forms.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "caspase",
    "NACHT domain-, leucine-rich repeat (LRR)-, and pyrin (N-terminal homology) domain (PYD)-containing protein 3",
    "cytokine",
    "interleukin"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1193 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/inflammasome/"
}