NACHT domain-, leucine-rich repeat (LRR)-, and pyrin (N-terminal homology) domain (PYD)-containing protein 3

{
  "id": "MLC-T-CHM-007740",
  "term": "NACHT domain-, leucine-rich repeat (LRR)-, and pyrin (N-terminal homology) domain (PYD)-containing protein 3",
  "field": "Chemistry",
  "definition": "An intracellular sensor protein that detects a wide array of microbial motifs, endogenous danger signals, and environmental irritants. Upon activation, this protein, also known as NLRP3, oligomerizes and recruits other proteins to form a large multiprotein complex called the inflammasome. The assembled inflammasome activates caspase-1, which in turn processes pro-inflammatory cytokines like interleukin-1β and interleukin-18 into their mature, active forms, driving inflammatory responses.",
  "synonyms": [
    "cryopyrin"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "NOD-like receptor",
    "cytokine",
    "inflammasome",
    "interleukin"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1218 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/nacht-domain-leucine-rich-repeat-lrr-and-pyrin-n-terminal-homology-domain-pyd-3/"
}